Do older people experience a greater post-meal inflammatory response to a fast food breakfast?

In older adults aged 70-75 years versus younger adults aged 20-25 years, does the ingestion of a high fat fast food breakfast, compared with a lower fat 'healthy' breakfast, elicit a greater post-meal inflammatory response.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000515897

Enrollment

Registered

2012-05-15

Start date

2012-10-19

Completion date

2013-07-09

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Meals high in fat cause a marked postprandial increase in low-grade inflammation. Although short-term, the resulting inflammatory response may have implications in long-term risk for chronic illness such as cardiovascular disease (CVD). It is unknown whether the postprandial inflammatory response to high-fat meals differs in older adults, and is still not clear how digestion and metabolism of fats is affected by age. This study aims to analyse the digestive, physiological, inflammatory and immune responses to a single meal in young adults compared with older adults, of either a ‘fast-food’ breakfast (high in saturated fat and calories), or a ‘healthy’ breakfast (low in saturated fat, following dietary guidelines set out by The Australian Guide to Healthy Eating).

Interventions

A single meal of a fast food breakfast of two sausage and egg breakfast sandwiches, and a hash brown, consisting of 4395 kJ, 63g fat, 75g carbohydrate and 43g protein. The meal is consumed for breakfast after an overnight fast (7pm to 7am) and followed by a two week wash-out period between study meals.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Aged 20-25 or 70-75 years old Non-vegetarian No allergies to peanuts, dairy, gluten

Exclusion criteria

Vegetarian Food allergies to peanuts, dairy, gluten Family history of diabetes Family history of heart disease Anti-inflammatory pharmaceutical use BMI >30

Outcome results