None listed
Conditions
Brief summary
This study aims to build on the work by Wisoff 2007 published in circulation that showed superior benefits of high intensity interval training over moderate intensity continuous training in heart failure patients. It is hoped that with a larger sample size and longer follow up and intervention period the primary outcome, mortality will be significantly improved.
Interventions
1. High intensity interval stationary cycle exercise training at 95% of maximum exercise capacity for 15-20 minutes (although patients will be required to be rpesent for 45-50 minutes to assess and prepare then and conduct warm-up/cool-down)them, thrice weekly for an overall duration of the training program of 6 months.
This gorup will exercise for 4 minutes and rest for 1 minute and then repeat this exercise;rest pattern 3-4 more times. Interval exercise with be preceded by a 5-10 minute warm-u
1. High intensity interval stationary cycle exercise training at 95% of maximum exercise capacity for 15-20 minutes (although patients will be required to be rpesent for 45-50 minutes to assess and prepare then and conduct warm-up/cool-down)them, thrice weekly for an overall duration of the training program of 6 months. This gorup will exercise for 4 minutes and rest for 1 minute and then repeat this exercise;rest pattern 3-4 more times. Interval exercise with be preceded by a 5-10 minute warm-up and 5-10 minute cool down. OR 2. Moderate intensity (70% maximum) continuous stationary cycling exercise training for 45-50 minutes, thrice weekly for an overall duration of the training program of 6 months.
Sponsors
University of New England
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Diagnosis of heart failure by echocardiography LVEF<40% any aetiology is accepted
Exclusion criteria
Myocardial infarction within prior 12 months. Change of medical therapy in the 3 months prior to study entry. Unstable angina Resting systolic blood pressure > 200 mm Hg, or diastolic blood pressure > 110 mm Hg, Systemic illness Fever and critical aortic stenosis (peak systolic pressure gradient > 50 mm Hg with an aortic valve orifice area > 0.75 cm2 in average size adult). Uncontrolled atrial or ventricular arrhythmias such as uncontrolled sinus tachycardia (> 120 beats.min-1), 3rd degree AV block, active pericarditis or myocarditis, recent embolism, thrombophlebitis and resting ST segment displacement (> 2 mm). Uncontrolled diabetes (resting blood glucose of > 400 mg/dL) Severe orthopedic conditions that would prohibit exercise Other metabolic conditions such as acute thyroiditis, hypokalemia or hyperkalemia and hypovolemia. dementia; any systemic disease limiting exercise; inability to participate in a prospective study for any logistic reason, chronic inflammatory disease
Outcome results
None listed