The role of mild cold exposure on heat production before and after a glucose load in overweight Australian adults with and without the metabolic syndrome.

Does mild cold acutely increase adaptive thermogenesis to a greater extent in those without the metabolic syndrome than those with the metabolic syndrome?

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000509864

Acronym

ATMS

Enrollment

Registered

2012-05-14

Start date

2012-09-03

Completion date

2012-11-02

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to understand how the body adapts to a mild cold temperature and whether this differs in people who have evidence of the following metabolic abnormalities: a large waist circumference, high blood fats, low "good" cholesterol, high blood pressure and high blood glucose levels. We believe that those who have these abnormalities will not be able to adapt as well to a cold temperature than those without the adnormalities. This will be detected by us as a smaller rise in metabolic rate and the healthy blood protein adiponectin, both before and after a simple meal, like glucose.

Interventions

Participants will rest in bed in a purpose built insulated room called a climatic chamber, where the temperature can be set and maintained for prolonged periods. Subjects will be studied on two separate occasions with a maximum interval of 2 weeks in between measurements. On one occasion the temperature will be 20 degrees centigrade and on another it will be 25 degrees centigrade. This is a crossover study so each participant will be studied at these two temperatures in a random order, separated by a washout period of 2 weeks. On each occasion measurements will last for approximately 4 hours. After recording baseline measurements for 1.5 hours, participants will consume a 300 ml glucose drink (75 grams of glucose in flavoured distilled water) and measurements will resume for the next 2 hours.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

Australians of European origin; overweight or obese with a body mass index (BMI) of greater than 25 kg/m2, weight stable within +/- 2 kg in the previous 6 months with no intention for weight loss within the next 6 months, with or without the metabolic syndrome.

Exclusion criteria

Fever, thyroid disease (by history); polycystic ovarian syndrome (by history); type II diabetes (by history); smoking; pregnancy; lactation; use of thermogenic agents; hormonal contraception; testosterone replacement therapy; hormonal replacement therapy and women who are peri-menopausal.

Outcome results