None listed
Conditions
Brief summary
Cardiovascular mortality and morbidity are high in end-stage renal disease (ESRD) patients compared to general population. Arterial stiffness is a cardiovascular measure that predicts mortality in ESRD patients. Although exercise can counteract many risk factors contributing to arterial stiffness, research on its effect on arterial stiffness in ESRD patients is inconclusive and limited to aerobic exercise. The aim of this project is to examine the affect of intradialytic resistance training on arterial stiffness and other secondary health outcomes in ESRD patients. Participants will undergo a 12 weeks usual care control period followed by a 12 weeks resistance training intervention period. Participants will be recruited from dialysis centres and will undertake their exercises in their centres. All participants will undergo a series of measurements before and after control period and after intervention period. Measures include arterial stiffness, blood sample measures, quality of life, depression level, physical fitness and activity level.
Interventions
Resistance exercise intervention: After 12 weeks of usual care and 1 week gap (testing period), participants proceed to 12 week intradialytic resistance training intervention conducted 3 times per week for approximately 30 minutes per session encompassing full body weight training. Moderate to high intensity, progressive resistance training (free weights, elastic tubings and machine) will be administered by an exercise physiologist. The training session will be conducted on an individual basis.
Resistance exercise intervention: After 12 weeks of usual care and 1 week gap (testing period), participants proceed to 12 week intradialytic resistance training intervention conducted 3 times per week for approximately 30 minutes per session encompassing full body weight training. Moderate to high intensity, progressive resistance training (free weights, elastic tubings and machine) will be administered by an exercise physiologist. The training session will be conducted on an individual basis. A generic set of exercises will be prescribed and progressed according to individual's rating of perceived exertion.
Sponsors
Danwin Chan
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
haemodialysis patients aged greater than or equal to 40 years medically stable, and adequately dialysed (Kt/V greater than or equal to 1.2) for greater than three months ability to ambulate independently or with an assistive device for more than or equal to 50m cognition and English language sufficient to understand research procedures and provide written informed consent sedentary (i.e. less than 120 minutes of moderate intensity physical activity per week)
Exclusion criteria
limb amputation, acute or chronic medical condition that contraindicates or prevents the performance of resistance training during hemodialysis treatment, current participation in an exercise regimen involving resistance training.
Outcome results
None listed