None listed
Conditions
Brief summary
This study aims to explore the impact of an imposed de-synchronisation between circadian rhythms, sleep cycles and eating patterns - as would occur during a rotation between day and night work, on postprandial dysmetabolism.
Interventions
In this study we will implement a protocol that simulates an industry standard 12-hour work shift (with basic computer based office work tasks).
Participants will be randomised initially, to either shift work condition (night shift first or day shift first). Once the first shift is complete there will then be a two week wash out period. Then the second shift will begin.
Both works shifts consist of 3 days of 12 hours (36 hour work week).
Sponsors
University of Sydney
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy volunteers, with no shift work experience
Exclusion criteria
Hypertriglycerdemia (TAG > 4mmol/dl), Impaired fasting glucose (>5.6 mmol/dL), Current shift worker, Moderate or worse OSA (AHI>15) or treated OSA, history of cardiovascular, renal or metabolic disease including stroke, coronary heart disease, kidney disease and diabetes (Type 1&2), other co-morbid sleep conditions (insomnia, sleep phase syndromes, narcolepsy etc) neurological or psychiatric disease that the investigators consider will alter normal sleep patterns.
Outcome results
None listed