The Glucose Tolerance Test Study

The effect of glucose on acute changes in circulating IL-6 concentrations in overweight individuals.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000491864

Enrollment

Registered

2012-05-07

Start date

2009-08-19

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Incretins are hormones that are produced in the intestine in response to food. The major increton is GLP-1 which directly stimulates the pancreas to produce insulin. The incretin effect is responsible for the greater insulin secretion seen after oral glucose intake compared to intravenous glucose. we postulate that after meal insulin changes are responsible for the reduction in circulating inflamatory marker IL-6 concentrations after an oral glucose tolerance test. If this is correct we believe that when the same amount of glucose is adminitered intravenously, due to a reduced insulin response, the after food decrease in IL-6 will be lessened.

Interventions

After fasting overnight 16 Participants will be given 75g glucose to take orally, at a seperate visit they will be given 75g glucose intravenously. As a control these participants will be given water. Following each 5 blood samples will be taken over a 2 hour period. There will be at least one week between each treatment.

Study design

Allocation

Non-randomised trial

Primary purpose

Educational / counselling / training

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

BMI > 27kg/m2 , have no ongoing health problems, not have diabetes, take no medication.

Exclusion criteria

Smoking, diabetes. Taking medications. BMI < 27kg/m2

Outcome results