Magnetic resonance imaging of the vision centre of the brain in visually impaired versus normally sighted participants

3-Tesla MRI volumetric and diffusion tensor analyses of the primary visual cortex: A case-control study in visually impaired and normally sighted subjects

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000476831

Enrollment

Registered

2012-05-01

Start date

2011-03-28

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We hypothesise that the structure of the primary visual cortex in severely visually impaired participants will differ from that in participants with normal vision. Our aim is to develop a method of identifying the primary visual cortex during exposure of the occipital lobe of the brain during neurosurgery.

Interventions

Detailed anatomical mapping of the primary cortex using high resolution magnetic resonance imaging in patients with severe visual impairment compared with normally sighted volunteers. Consists of a single brain MRI of the occipital lobe of 60 minutes' duration.

Study design

Allocation

Non-randomised trial

Intervention model

Other

Primary purpose

Diagnosis

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Cases: untreatable bilateral visual impairment due to retinitis pigmentosa, diabetic retinopathy, glaucoma or macular degeneration or with acquired retinal, optic nerve or ocular surface disease. Visual acuity of less than or equal to Snellen’s Test Type 6/60 for > 12 months. History of normal vision in adulthood. Controls: visual acuity of greater than or equal to Snellen’s Test Type 6/12. Intact visual cortex Age greater than or equal to 18 years

Exclusion criteria

History of traumatic occipital cortex injury Cognitive or intellectual disability, or dementia Pre-existing active psychiatric conditions including psychosis, bipolar disorder and schizophrenia Claustrophobia

Outcome results