None listed
Conditions
Brief summary
This research will define the mechanisms underlying the presence of gastroesophageal reflux (GOR) in individuals with obstructive sleep apnoea (OSA). Both are common conditions with OSA affecting 1 in 20 individuals and GOR affecting approximately 1 in 12 individuals in the community. Continuous positive airways pressure (CPAP), the most common and effective treatment for OSA has also been found to treat GOR. GOR symptoms are more common in OSA than the general population (14% vs 5%) and increase with increasing OSA severity. Nighttime GOR is a particular worry in individuals with OSA with 1 in 3 OSA patients reporting overnight symptoms. GOR has significant negative health effects in individuals with OSA including painful symptoms and an increase in cancer risk. Identification of the reasons for the increased incidence of reflux in OSA may assist in improving prevention and/or treatment of GOR in individuals with OSA as well as increasing quality of life in these patients. Aims The overall aim of the proposed research is to determine the underlying reason for the presence of gastroesophageal reflux (GOR) in individuals with obstructive sleep apnoea (OSA), including the roles of obesity and arousal from sleep. Furthermore, we aim to determine the effect of OSA treatment with CPAP therapy on nighttime GOR in individuals with and without OSA. . Methods We aim to recruit a total of 80 individuals of mixed gender between the ages of 18 and 70 years of age. Each participant will undergo a 24 hour pH-impedance study for assessment of reflux severity, an overnight sleep study and a DXA scan to assess obesity and fat distribution; or a 48hour recording of oesophageal pH with two consecutive overnight sleep studies, of with CPAP therapy and one without, in a randomised fashion.
Interventions
The proposed research will investigate the underlying reason for the presence of increased gastroesophageal reflux (GOR) in individuals with obstructive sleep apnoea (OSA) and the effect of OSA treatment on nighttime GOR. In order to examine the role of obesity and arousal from sleep in the presence/severity of nighttime GOR, participants will will undergo in laboratory polysomnography, a 24-hour oesophageal pH-impedance recording and a full body dual energy x-ray absorptiometry scan. In order
The proposed research will investigate the underlying reason for the presence of increased gastroesophageal reflux (GOR) in individuals with obstructive sleep apnoea (OSA) and the effect of OSA treatment on nighttime GOR. In order to examine the role of obesity and arousal from sleep in the presence/severity of nighttime GOR, participants will will undergo in laboratory polysomnography, a 24-hour oesophageal pH-impedance recording and a full body dual energy x-ray absorptiometry scan. In order to examine the effect of CPAP on nighttime GOR in those with and without OSA, participants will undergo 2 consecutive sleep studies and a 48-hour oesophageal pH recording (wireless capsule based measurement, placed during gastroscopy). One of the sleep studies will be with CPAP therapy (set at 10cmH20), and the other night without CPAP. This order will be randomised. Involvement in the study will span up to 72 hours total.
Sponsors
University of Western Australia
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
18-70 years of age of mixed gender with no significant co-morbidity.. Participants were recruited from patients who had undergone a gastroscopy for investigation of GOR symptoms in the previous 12 months.
Exclusion criteria
Uncontrolled hypertension, ischaemic heart disease, type I diabetes or depression. Previous oesophageal or gastric surgery Gastroesophageal disorders such as lupus, coeliac disease or ulcerative colitis.
Outcome results
None listed