None listed
Conditions
Brief summary
Red blood cell (RBC) transfusion is a very common and potentially life-saving treatment in intensive care units (ICUs). However, RBC transfusion has also been associated with an increased risk of morbidity and/or mortality in critically ill, surgical and trauma patients. Although this association is multifactorial, attention has increasingly focused on the possible adverse impact of transfusing RBC which have been stored for a prolonged time.The primary aim of the trial is to determine if transfusion of the freshest available RBC in critically ill patients compared to standard care decreases patient mortality.
Interventions
Experimental: These patients will receive the freshest available group-specific compatible RBC unit in the transfusion service.
Indication,timing and number of RBC units will be determined as per standard practice by the clinician for each individual situation.
Sponsors
Monash University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients hospitalised in ICU with an anticipated ICU stay of at least 24 hours, in whom the decision has been made by medical staff to transfuse at least one RBC unit.
Exclusion criteria
Age younger than 18 A previous RBC transfusion during the current hospital admission (including transfusion in another hospital for transferred patients) Diagnosis of transplantation or hematologic diseases Pregnancy Cardiac surgery during the present hospital admission Expected to die imminently (<24hrs) The treating physician believes it is not in the best interest of the patient to be randomised in this trial. Known objection to the administration of human blood products Participation in a competing study
Outcome results
None listed