Does Intravenous iron therapy reduce the need for blood transfusion and improve post operative blood count following surgery for broken neck of femur.

Intravenous iron infusion to reduce transfusion and post operative haemoglobin in patients with fractured neck of femur

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000448842

Acronym

IronNOF

Enrollment

173

Registered

2012-04-19

Start date

2013-02-18

Completion date

2017-05-29

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

As the population ages there is an increasing number of elderly patients presenting to hospital with fractured hips. A large proportion of these patients receive blood transfusions, a treatment that is associated a significant cost and potential harm. Most of these patients being transfused have an iron deficiency anaemia. We plan to examine the benefit of giving intravenous iron to these patients to see if we can reduce the number needing a blood transfusion and improve nadir haemoglobin and ultimately reduce length of stay and 6 month mortality

Interventions

Intravenous Iron Infusion. This will be given as a single 50ml infusion over 15 mins with a dose of up to 1000mg of iron carboxymaltose based on the Ganzoni formula. The infusion will be commenced prior to surgical closure.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

Fractured neck of Femur Surgical fixation planned

Exclusion criteria

Surgery required in <6 hrs Haemochromatosis Previous adverse reaction to Intravenous Iron Blood transfusion prior to screening

Outcome results