None listed
Conditions
Brief summary
It is well established that oxygen therapy can increase carbon dioxide in patients with chronic obstructive pulmonary disease. However, the dose-response relationship is unknown, in particular whether this effect occurs above a certain oxygen concentration threshold. This needs to be explored to ensure guidelines appropriately recommend oxygen prescription to minimise the incidence of hypercapnia (high carbon dioxide levels). We plan to explore this with a randomised controlled four way cross over clinical trial of varying concentrations of oxygen therapy in chronic obstructive pulmonary disease patients.
Interventions
Oxygen administered to all participants at 28, 35 and 50%, each for 30 minutes with a 30 minute washout period following, via a venturi mask system.
Sponsors
Janine Pilcher
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Diagnosis of chronic obstructive pulmonary disease with oxygen induced elevation in transcutaneous carbon dioxide levels of greater than or equal to 4mmHg.
Exclusion criteria
An intercurrent chest infection FEV1:FVC >0.7 Baseline transcutaneous carbon dioxide of greater than 60mmHg Diagnosis of a disease causing restriction to chest wall expansion (neuromuscular disease or chest wall dysfunction) Obesity (body mass index greater than or equal to 40) Any other condition which, at the investigator's discretion, is believed may present a safety risk or impact the feasibility of the study or the study results.
Outcome results
None listed