None listed
Conditions
Brief summary
The primary purpose of this study is to determine the efficacy of remifentanil infusion for alleviating pain in neonates requiring insertion of central venous lines for their medical care.
Interventions
Remifentanil syringes are loaded onto Braun infusion pumps and infused at 1 mL/kg/hour for 15 mins prior to commencement of the procedure. The neonate will recieve an intravenous infusion 0.1 mcg/kg/min remifentanil until central catheter has been threaded to its final position and secured OR until the central catheter has been threaded to its final position and all procedural activity has paused awaiting confirmation of catheter tip position by imaging (accepting that not all operators secure t
Remifentanil syringes are loaded onto Braun infusion pumps and infused at 1 mL/kg/hour for 15 mins prior to commencement of the procedure. The neonate will recieve an intravenous infusion 0.1 mcg/kg/min remifentanil until central catheter has been threaded to its final position and secured OR until the central catheter has been threaded to its final position and all procedural activity has paused awaiting confirmation of catheter tip position by imaging (accepting that not all operators secure the line at this time) at which time the infusion will be ceased.
Sponsors
Dr Susan M Lord
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
24 Weeks to 44 Weeks
Healthy volunteers
No
Inclusion criteria
Medically stable neonates Inpatient in JHCH NICU Level 3 Nursery Require insertion of a central venous catheter for their medical care 24–44 weeks corrected gestational age at the time of procedure
Exclusion criteria
Prior participation in this study (an infant can only participate once) Major congenital anomalies Severe hypoxic ischaemic encephalopathy Current clinical seizures Concomitant muscle relaxant Emergency central line insertions Lack of peripheral venous access for administration of study drug
Outcome results
None listed