High Concentration Oxygen in Fibrotic Lung Disease

Response of Patients with Fibrotic Lung Disease to Hyperoxia and Normoxia, as Measured by Carbon Dioxide Levels

Status

Suspended

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000381886

Enrollment

Registered

2012-04-03

Start date

2013-07-24

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Oxygen therapy has been shown to increase carbon dioxide in the blood of patients with certain repiratory conditions. This study aims to find out if oxygen therapy increases carbon dioxide levels in patients with fibrotic lung disease and, if so, how.

Interventions

50% oxygen administration for 30 minutes via a full-face continuous positive airway pressure mask without positive airway pressure. Followed by a 30 minute washout period.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Fibrotic lung disease by doctor's diagnosis and evidence of fibrosis on CT scanning

Exclusion criteria

Baseline transcutaneous carbon dioxide of greater than or equal to 60mmHg Diagnosis of chronic obstructive pulmonary disease FEV1:FVC less than or equal to 70% Vital capacity greater than 80% Over 20 pack year smoking history Obesity (body mass index greater than or equal to 40) Any other condition which, at the investigator's discretion, is believed may present a safety risk or impact the feasibility of the study or the study results

Outcome results