Role of probiotics in improving post-colonoscopy symptoms and earlier return of normal bowel function

Role of oral probiotics in improving post-colonoscopy symptoms and earlier return of normal bowel function in patients undergoing colonoscopy after full mechanical bowel preparation

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000377831

Enrollment

200

Registered

2012-04-03

Start date

2012-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Mechanical bowel preparation causes a marked imbalance in the colonic microflora. This altered microflora may play a significant role in post-preparation symptoms and delay in return of the normal bowel function for that patient. AIM Evaluate the benefit of probiotic use, and associated restoration of the balance of intestinal microflora, for patients undergoing colonoscopy after mechanical bowel preparation. METHODS Prospective double-blinded randomised control trial. Use of probiotics vs placebo in the setting of patients who have undergone full mechanical bowel preparation and colonoscopy A commercially available probiotic or placebo at recommended daily dose for 7 days after the procedure END POINTS Evaluation of post-colonoscopy symptoms - Abdominal pain - Time taken for patient bowel function to return to normal (the usual bowel habit for them)

Interventions

High Potency Probiotic Capsules containing Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07, once daily for 7 days post-colonoscopy

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

A patient who has completed full mechanical bowel preparation for a colonoscopy

Exclusion criteria

Failure to complete full mechanical bowel preparation Enema preparation only for a flexible sigmoidoscopy

Outcome results