High Concentration Oxygen in Bronchiectasis

Response of Patients with Bronchiectasis to Hyperoxia and Normoxia, as Measured by Carbon Dioxide Levels

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000356864

Enrollment

Registered

2012-03-28

Start date

2012-06-12

Completion date

2013-12-04

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Oxygen therapy has been shown to increase carbon dioxide in the blood of patients with certain respiratory conditions. This study aims to find out if oxygen therapy increases carbon dioxide levels in patients with bronchiectasis and, if so, how.

Interventions

50% oxygen administration for 30 minutes via a full-face continuous positive airway pressure mask without positive airway pressure. Followed by a 30 minute washout period.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

14 Years to No maximum

Healthy volunteers

Inclusion criteria

Bronchiectasis diagnosed by a doctor and confirmed on CT scanning.

Exclusion criteria

Diagnosis of infection with Burkholderia Baseline transcutaneous carbon dioxide level of greater than or equal to 60 mmHg Diagnosis of chronic obstructive pulmonary disease Over 10 pack year smoking history Obesity (body mass index equal to or greater than 40) Any other condition which, at the investigator's discretion, is believed may present a safety risk of impact feasiblity of the study of study results

Outcome results