None listed
Conditions
Brief summary
‘Isofurans’ are a group of compounds that are produced by the body when it is exposed to high levels of oxygen. It is a relatively new discovery (2002) and reflects the amount of stress to the body caused by exposure to oxygen. There is still a good deal we do not know about this subject, however it could be linked to a number of illnesses, including Parkinson’s and certain types of lung and eye injuries. We aim to study the production of Isofurans under high oxygen pressures (hyperbaric), which has not been done before. The study will involve taking blood samples from patients who require hyperbaric treatment to improve bone production after radiotherapy, and monitoring the effect this has on Isofurans levels.
Interventions
Measuring Isofurans compound levels in serum during hyperbaric treatment. We will be taking 7 blood samples (through one peripheral cannula) during the first hyperbaric treatment of a patient with radio-osteonecrosis. The serum levels of Isofurans (and other routine bloods such as a full blood picture / urea and electrolytes) will be recorded. The duration of this study is expected to be 12 months from beginning of data collection (i.e. finish date by June 2013)
Sponsors
Dr. Tomas Corcoran
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients currently booked for hyperbaric therapy to treat osteonecrosis secondary to radiation therapy 2. 18 years and over
Exclusion criteria
1. Active systemic infection / inflammatory disease 2. Any risk factors for barotrauma 3. Current steroid use
Outcome results
None listed