None listed
Conditions
Brief summary
The initial aim of the study was to examine either the effects of administration of anti-lipolytic drug Acipimox or placebo during short-term exercise on plasma adrenocorticotropic hormone (ACTH) and free fatty acid (FFA) levels in bulimia nervosa (BN) patients and healthy women. The secondary aim was to find whether FFA are involved in exercise-induced ACTH release in BN and the controls. Healthy women were also feature in this study.
Interventions
All participants were randomized to receive either placebo or Acipimox (Aci) capsules each week (two 250 mg capsules of Aci or placebo; 500 mg total – 5-methylpyrazine-2-carboxylic acid 4-oxide, molecular weight: 154.1, Olbetam capsules, Farmitalia Carlo Erba, Milan, Italy) 1 hour before a single exercise bout, e.g. two capsules each week for a total of 2 weeks. A low- to moderate-intensity exercise bout on an electromagnetically braked bicycle ergometer (Cateye EC 1600, Japan) was performed for
All participants were randomized to receive either placebo or Acipimox (Aci) capsules each week (two 250 mg capsules of Aci or placebo; 500 mg total – 5-methylpyrazine-2-carboxylic acid 4-oxide, molecular weight: 154.1, Olbetam capsules, Farmitalia Carlo Erba, Milan, Italy) 1 hour before a single exercise bout, e.g. two capsules each week for a total of 2 weeks. A low- to moderate-intensity exercise bout on an electromagnetically braked bicycle ergometer (Cateye EC 1600, Japan) was performed for 45 min at power output 2W/kg of lean body mass (LBM), intended to be below the aerobic-anaerobic threshold. The exercise was performed individually but all participants during the exercise were connected personally with their nurses and attending physicians. Healthy women were also feature in this study. This is a second arm of the study consisting of matched, healthy controls. Healthy women also took the placebo or Aci capsules.
Sponsors
Ministry of Health
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
age between 18 and 30 years, BMI between 18 and 23 kg/m2, patients with a diagnosis of bulimia nervosa (Diagnostic and Statistical Manual of Mental Disorders, DSM-IV, 4th edition, text revision, American Psychiatric Association, 2000).
Exclusion criteria
hypertension, abnormal blood tests with significant hyperlipidaemia, and history or presence of hepatic or renal disorders All eligible participants were deemed healthy.
Outcome results
None listed