None listed
Conditions
Brief summary
To assess whether anaesthetic gases in trauma patients may contribute to liver damage.
Interventions
Trauma patients admitted and undergoing surgical procedures will have their liver function assessed during admission to ascertain the development of liver disease, potentially resulting from exposure to volatile anaesthetic agents. VALDA occurs typically within days of exposure, and therefore patients will have repeat LFTs taken on admission, and then on days 1, 4, 8 and 12 postoperatively. Those with a characteristic pattern of dysfunction will be followed up with immunoassay, to confirm the de
Trauma patients admitted and undergoing surgical procedures will have their liver function assessed during admission to ascertain the development of liver disease, potentially resulting from exposure to volatile anaesthetic agents. VALDA occurs typically within days of exposure, and therefore patients will have repeat LFTs taken on admission, and then on days 1, 4, 8 and 12 postoperatively. Those with a characteristic pattern of dysfunction will be followed up with immunoassay, to confirm the development and presence of antibodies typically seen in immune-mediated liver dysfunction (anti-trifluoroactate [TFA] antibodies). Those with abnormal liver function will be followed up by a hepatologist.
Sponsors
Brad Hockey
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Trauma patients admitted to Royal Melbourne Hospital.
Exclusion criteria
No consent.
Outcome results
None listed