Screening for Abdominal Aortic Aneurysms: Improved detection by targeting high risk individuals.

Does ultrasound screening of cardiovascular disease patients result in improved Abdominal Aortic Aneurysm detection rates in comparison with an age & gender model?

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612000244808

Enrollment

2000

Registered

2012-02-28

Start date

2012-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

While NZ does not currently have an Abdominal Aortic Aneurysm (AAA) screening programme, internationally ultrasound screening programmes are generally offered to males aged 65 or greater. This excludes women and those who develop AAA at a younger age and have more to gain from early detection. Our previous studies have identified that people with a history of arterial disease have a significantly greater risk of developing AAA. This trial will prospectively screen individuals with arterial disease or elevated cardiovascular disease (CVD) risk to validate these findings. Recruitment and screening will be undertaken through existing primary and secondary CVD healthcare providers to assess whether or not such a targeted approach delivered through existing services could be a viable screening strategy for NZ

Interventions

A single transcutaneous ultrasound (US) scan of the abdomen will be performed to assess the presence or absence of abdominal aortic aneurysm (AAA). A blood sample will also be taken for analysis of genetic and biomarkers associated with AAA and other cardiovascular disease. This is a single consultation of approximately 20 minutes duration.

Eligibility

Sex/Gender

All

Age

50 Years to 90 Years

Healthy volunteers

Inclusion criteria

Clinically documented cardiovascular disease (CVD); or Elevated cardiovascular disease risk factors (Heart Foundation CVD score of moderate (15-20%) 5-year event risk or higher).

Exclusion criteria

Age <50 years as Abdominal Aortic Aneurysm seldom develops before this age. Age >90yrs as treatment options are limited and the risk of rupture is likely to be less than the risk of surgical repair.

Outcome results