Effect of steroids on blood sugar levels and risk of heart disease in pituitary patients

Effect of glucocorticoid replacement dose on cardiovascular risk and postprandial blood glucose in hypopituitary patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000234819

Enrollment

Registered

2012-02-23

Start date

2011-02-25

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to assess whether higher doses of steroids increase the risk of heart disease in pituitary patients. We hope that this study will increase the understanding of the effects of steroid replacement dose in patients with pituitary disorders. This information may influence what doses of steroid replacement are optimal for the long-term health of pituitary patients.

Interventions

An open interventional study assessing the effect of increasing oral glucocorticoid dose on arterial stiffness, endothelial function and autonomic nervous system activity. Subjects will be studied on their usual oral glucocorticoid dose and then again after increasing their oral glucocorticoid dose to hydrocortisone equivalent 30 mg/day for 7 days. At each study visit, subjects will be studied before and after drinking an oral glucose load (75 g)

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Educational / counselling / training

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

Hydrocortisone less than or equal to 20mg per day (or other glucocorticoid at equivalent dose) GC use for at least 6 months Age greater than or equal to 20 years

Exclusion criteria

Atrial fibrillation Beta blocker medication Raynaud’s phenomenon Inability to provide written informed consent On treatment for diabetes

Outcome results