None listed
Conditions
Brief summary
Overweight and obesity can result in impaired or high glucose levels and aberrant vascular function, which leads to metabolic syndrome (MetS), pre-diabetic (PD), or type 2 diabetes. Early detection of impaired glucose levels in overweight/obese individuals is desirable to prevent the likelihood of disease progression. Thus, the purpose of this study, is firstly to identify early markers, such as impaired/high glucose level and aberrant vascular function in overweight/obese individuals, and secondly, to examine the acute effect of aerobic exercise on those early markers. It is expected that acute exercise will normalize vascular function aberration in MetS and PD individuals.
Interventions
Subjects will be required to attend three testing sessions over 4 days with at least 24 hours (1 day) of recovery day between Session 2 and 3. In Session 1 (day 1), subjects will undergo a glucose tolerance test (GTT). Based on the GTT results subjects then will be categorized into normal, impaired, or high glucose levels. In Session 2 (day 2), subjects will be required to perform maximal oxygen uptake (VO2max) test to determine the exercise load that will be used in Session 3. In Session 3 (day
Subjects will be required to attend three testing sessions over 4 days with at least 24 hours (1 day) of recovery day between Session 2 and 3. In Session 1 (day 1), subjects will undergo a glucose tolerance test (GTT). Based on the GTT results subjects then will be categorized into normal, impaired, or high glucose levels. In Session 2 (day 2), subjects will be required to perform maximal oxygen uptake (VO2max) test to determine the exercise load that will be used in Session 3. In Session 3 (day 4), subjects will perform a single bout of moderate intensity exercise on the bike for 30 min. All variables will be measured at pre and post acute exercise. During exercise subjects will be supervised and their heart rate will be monitored every 2 min by the tester/researcher.
Sponsors
University of New South Wales
Study design
Allocation
Randomised controlled trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
Young individuals with body mass index (BMI) ranging between 25-35 kg/m2; non athletes (exercise no more than 3 times/week for 30 min each session; free of medication and diseases. Also, they will posses metabolic syndrome criteria (waist circumference greater than or equal to 94 cm and any two of the following: triglyceride level greater than or equal to 1.7 mmol/L; HDL cholesterol <1.03 mmol/L; systolic blood pressure greater than or equal to 130 mmHg or diastolic blood pressure greater than or equal to 85 mmHg; fasting plasma glucose greater than or equal to 5.6 mmol/L) and high glucose levels following a glucose tolerance test.
Exclusion criteria
Trained individuals (athletes); diabetes; use of medications; hypertension
Outcome results
None listed