Using ketamine (an anesthetic agent) with Propofol (a hypnotic agent commonly used during sedation) during visual examination of large intestine reduces propofol dosage improves the quality of sedation

Propofol in combination with ketamin reduces propofol dosage and improves quality of sedation during colonoscopy: A prospective, randomized and double blind study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000162819

Enrollment

100

Registered

2012-02-06

Start date

2010-09-20

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Propofol is frequently used for sedation in endoscopy units. Usually opioids are used in combination to propofol in order to improve the quality of sedation. However combining opioids with propofol usually raises the incidance of adverse events such as apnea. Ketamine is usually used for sedation for invasive procedures outside the operating room especially in children. Its not preffered in adults for sedation because of agitation and hallucinations which can be prevented by using sedative or hypnotic agents. The most important advantage of using ketamine is that it does not supress the airway reflexes. Thus it can be hypotised that ketamine may be a better agent of choice than opioids to combine with propofol during sedation. The aim of this study is to investigate the effects of ketamine added to propofol in terms of propofol sparing effects, quality of sedation, adverse events and recovery times.

Interventions

Patients were randomized to 2 groups according to applied sedation protocol as follows. Group 1: intravenous bolus saline was administred before propofol Group 2: intravenous bolus 0.25 mg/kg ketamine was administered before propofol. In each group propofol dosage was titrated according to patients sedation level. For both groups target sedation level was 1-2 with Modified Observer's assessment of Alertness/Sedation Scale.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

ASA I-II patients undergoing colonoscopy under sedation

Exclusion criteria

Use of anti-anxiety medicine within 48 hours before the procedure, past history of anorectal, colonic and gynecologic surgery and complaint of pain at the anal area precluding examination

Outcome results