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The Body, Brain, Life Program –a prevention trial to reduce risk of Alzheimer's Disease

The Body, Brain, Life Program -Evaluation of a multi-domain, online lifestyle intervention in middle-aged adults at risk of Alzheimer’s

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12612000147886
Acronym
BBL
Enrollment
176
Registered
2012-02-01
Start date
2012-07-01
Completion date
2013-03-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project is a randomised control trial of an online program that aims to reduce risk for Alzheimer’s disease (AD) by intervening in modifiable risk factors. The sample will be healthy but have several modifiable risk factors for AD. Hence this is classified as an indicated prevention trial. The intervention will educate individuals about AD and risks for AD. The intervention itself is tailored to individuals based on their readiness for change and level of risk in particular domains. There will be three groups; a control group who receives a pre and post assessment, an online only intervention group and an online plus small face-to-face intervention group. The trial involves 7 modules (one per week). Level of risk for AD will be assessed at baseline, 13 weeks and 26 weeks.

Interventions

The BBL program is an online, theoretically-driven, multi-domain intervention comprising seven modules (Dementia literacy, Risk factors literacy, engagement in physical, cognitive, and social lifestyles, nutrition, and health monitoring and management). All modules were designed in a manner reflective of current theoretical models of health behaviour change, and with the exception of the first two modules which are primarily educational in nature, will be delivered in an individually-tailored ma

The BBL program is an online, theoretically-driven, multi-domain intervention comprising seven modules (Dementia literacy, Risk factors literacy, engagement in physical, cognitive, and social lifestyles, nutrition, and health monitoring and management). All modules were designed in a manner reflective of current theoretical models of health behaviour change, and with the exception of the first two modules which are primarily educational in nature, will be delivered in an individually-tailored manner. The BBL program was designed to be delivered over 12 weeks, starting with the delivery of the seven modules once per week in a fixed order, and continuing with associated goal-related sessions in the remaining weeks. Participants in the intervention arms will be required to complete online activities 1 hour per week. They will be, however, encouraged to engage with the online material more frequently than that. Arm1; This group will complete the online BBL program as described above over 12 weeks (one hour per week). Arm2: This group will also complete the online BBL program over 12 weeks. However, this group will also participate in weekly face-to-face sessions to evaluate any additional effects of face-to-face contact, over and beyond the effects of the online trial only. Small face-to-face group sessions will be facilitated by a psychologist. The content of these sessions will largely echo the respective online modules. They will include discussion of the various risk factors, and will use motivational techniques to elicit group-level behavioural change dynamics. The small group element will be conducted weekly for 7 weeks with each week focusing on the topic of one of the online modules.]These face-to-face sessions will be of approximately one hour in duration.

Sponsors

Professor Kaarin J anstey
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
50 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

Persons aged 50 to 60, showing 3-4 AD modifiable risk factors on the ANU-ADRI, and who live in the ACT area. All participants will be required to have internet access at home, and they will need to agree to attend the Centre for Research on Aging, Health, and Wellbeing for two face-to-face assessments (baseline and 26 weeks)

Exclusion criteria

A diagnosis of any dementia, mild cognitive impairment, or cognitive impairment of any cause (MMSE<26). History of neurological conditions likely to affect cognition (e.g., parkinsonism, traumatic brain injury, significant stroke) Significant functional disabilities, for example due to hearing loss, vision impairment, or other medical events or procedures. Significant psychological illness, for example due to psychosis, schizophrenia, or bipolar disorder. No internet access at home, Not fluent in English

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 24, 2026