Total and free serum Ropivacaine Concentrations for patients receiving Continuous Transversus Abdominis plane block for Postoperative analgesia after abdominal surgery: Pilot Study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000104853

Acronym

ROP- CON study

Enrollment

Registered

2012-01-23

Start date

2011-10-05

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a pilot study looking into safety of giving bolus of ropivacaine followed by continous infusion for 48 hrs in Transversus Abdominis Plane Block. Safety of this regime will be established by serial blood samples to analyse toal & free ropivacaine concentration , Serail ECG 's looking into QTc interval & patient will be observed for sign & symptoms of Local anaesthetic toxicity

Interventions

Patients having mid line incision will have TAP block catheter towards the end of surgery. They will recieve 20 mls of 0.5% ropivacaine Bilateral (both sides) followed by continous infusion of 10mls/hr of 0.2% ropivacaine for 48hrs which will be started 30mins post 2nd bolus.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

Elective/Emergency abdominal surgery Between 18 and 80 years of age ASA less than 4 Adequate English language skills

Exclusion criteria

1 Allergy to local anaesthetic 2 Pt refusal 3 ASA score > 4 (i.e 4,5) 4 Pregnancy 5 On regular opioid medication or any other medication for chronic pain management. 6 Mental handicap or psychiatric condition precluding adequat communication. 7 Patients taking ciprofloxacin & fluvoxamine (affects the metabolism of LA) 8 Qt c interval > 0.45 sec in males and > 0.47 sec in females 9 Drugs affecting Qtc interval e.g. Haloperidol, Amiodarone, Sotaol

Outcome results