None listed
Conditions
Brief summary
This study aims to determine if immediate exercise therapy can improve health by reducing initial adverse effects during the initial phase of AST and if this provides superior benefits to delayed exercise therapy. Who is it for? You may be eligible to join this study if you are a man with prostate cancer who is about to initiate AST. Trial details. Participants in this trial will be randomly (by chance) allocated to one of two groups. One group will immediately undergo supervised exercise training 3 times per week for 6 months. This involves aerobic (walking/jogging, cycling, rowing), resistance (lifting weights), and impact (hopping, jumping) exercises and then monitored (without training) for a further 6months. The other group will be assigned to usual care for the first 6 months. After this time participants in this group will commence the exercise program for the next 6 months. Participants will have measurements of bone mineral density, body composition, blood markers, blood pressure, arterial stiffness taken at 4 occasions (baseline, 3-, 6-, and 12-months). Participants will also complete tests of their muscle strength, balance and physical function as well as complete a series of questionnaires at these time points.
Interventions
Immediate Exercise Group:
The exercise program involves resistance (e.g. lifting weights), aerobic (e.g. walking, cycling, rowing ergometer) and impact-loading (e.g. hopping, jumping) exercises undertaken 3 times per week for 6 months in an exercise clinic. Sessions will take approximately 60 minutes including the warm-up and cool-down periods. The sessions will be conducted in small groups of up to 6-10 participants under the supervision of exercise physiologists. The exercise program will be t
Immediate Exercise Group: The exercise program involves resistance (e.g. lifting weights), aerobic (e.g. walking, cycling, rowing ergometer) and impact-loading (e.g. hopping, jumping) exercises undertaken 3 times per week for 6 months in an exercise clinic. Sessions will take approximately 60 minutes including the warm-up and cool-down periods. The sessions will be conducted in small groups of up to 6-10 participants under the supervision of exercise physiologists. The exercise program will be tailored to each participant. Target intensity will be 60-85% estimated maximum heart (220 – age) for aerobic exercise and 6-12 repetition maximum (i.e. a 6 repetition maximum is how much weight can be lifted 6 times) for resistance exercise.
Sponsors
Edith Cowan University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
Male
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Men initiating androgen supression therapy (AST) for the treatment of prostate cancer
Exclusion criteria
1) Prior exposure to AST (e.g. those re-initiating AST from intermittent programs) 2) Established metastatic bone disease 3) Established osteoporosis 4) Taking medications known to affect bone metabolism (e.g. bisphosphonates), 5) Any acute illness, musculoskeletal, cardiovascular or neurological disorder that could inhibit a participant's ability to participate in the exercise program or put them at risk of injury or illness.
Outcome results
None listed