None listed
Conditions
Brief summary
A research study into how muscle bulk, strength and physical performance predict clinical outcomes in patients on dialysis. If the hypothesis proves to be correct, then these simple tests could be used when people are on dialysis or considering commencing dialysis. The results could highlight patients at increased risk of suffering medical complications during dialysis treatments.
Interventions
Measurement of: - biochemical parameters by serum assay of albumin, haematocrit, urea, cholesterol, CRP, transferrin, TNF-alpha - muscle mass using a Fresenius bioimpedance spectrometer - muscle strength using Jamar hand dynamometer for grip strength and isometric muscle strength dynamometer for leg extension - functional muscle capacity using repeated chair stands, timed up-and-go, and 6 minute walk test - subjective nutritional status assessment using the validated "Subjective Global Analysis"
Measurement of: - biochemical parameters by serum assay of albumin, haematocrit, urea, cholesterol, CRP, transferrin, TNF-alpha - muscle mass using a Fresenius bioimpedance spectrometer - muscle strength using Jamar hand dynamometer for grip strength and isometric muscle strength dynamometer for leg extension - functional muscle capacity using repeated chair stands, timed up-and-go, and 6 minute walk test - subjective nutritional status assessment using the validated "Subjective Global Analysis" questionnaire. Testing is performed during a single 45 minute assessment session at baseline, biochemical results are accessed from medical records, and TNF-alpha will be assayed from serum samples.
Sponsors
Associate Professor Grahame Elder
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Dialysis patients
Exclusion criteria
Cardiac pacemaker or implanted defibrillator Limb amputation
Outcome results
None listed