Mitochondrial function and markers of oxidative stress in patients with organ failure

Peripheral blood taking to measure mitochondrial function and markers of oxidative stress in patients with organ failure.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12612000047897

Acronym

MOSS

Enrollment

Registered

2012-01-10

Start date

2011-03-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Multiple organ dysfunction syndrome (MODS) is the primary cause of mortality and morbidity in intensive care units. MODS is associated with common intensive care unit diseases such as severe sepsis, septic shock, hemorrhagic shock and severe acute pancreatitis. In MODS, despite adequate delivery of oxygen, cells are not able to use this oxygen. This phenomenon is called cytopathic hypoxia and is thought to be due to mitochondrial dysfunction (MD). In health, mitochondria utilise most of the oxygen delivered to cells to generate the energy currency of cells called adenine triphosphate. However, it is not known what happens to mitochondrial function as MODS progresses and whether mitochondrial function (MF) can predict severity of organ failure. It is also not known whether the pattern of MD is similar in diseases such as shock with sepsis, and shock without sepsis compared to healthy volunteers. This study will measure MF from peripheral blood at multiple time points from patients with shock with sepsis, shock without sepsis and healthy volunteers in order to answer these questions. Often, after many months after discharge from intensive care unit, patients continue to still feel fatigued, it is not known whether this fatigue has any correlation with MF. This study will also address this question.

Interventions

A. Peripheral blood taking daily for the first 7 days, once at 3 weeks and once at 6 months from the time of organ failure (OF) in septic shock or shock without sepsis. Participants will be recruited over a 18 month period B. Filling out a fatigue questionnaire (Identity-Consequence Fatigue Scale) at each time point when blood is taken as practical

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

For patients: Over 15 with either septic shock or shock from any other cause. All patients must have organ failure of one or more organ systems. For heathy volunteers: Over 15 without any known medical conditions and not on any medications. Age and gender matched to patients. Eligible healthy volunteers will be deemed healthy with a help of a questionnaire detailing their medical history.

Exclusion criteria

Exclusion criteria for patients: Known mitochondrial diseases, hematological malignancies are the exclusion criteria for participating patients.

Outcome results