Central Sensitization Modulates Low Back Muscle Recruitment Patterns and Perceived Effort During Static Low Back Stabilizing Exercises

The comparison of the effect of central sensitization evoked by topical capsaicin cream versus non-sensitizing placebo cream on the muscle activation patterns in the lumbar spine and perceived effort during static low back stabilizing exercises in young healthy subjects.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000039886

Enrollment

Registered

2012-01-10

Start date

2012-01-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this project is to investigate the effect of central sensitization (increased excitability of the central nervous system) on the recruitment and perceived effort of low back muscles during static low back stabilizing exercise. We will compare the activation patterns and subjective measures of perceived contraction intensity before and after the experimental induction of central sensitization. This data important to the understanding of the mechanisms of low back injury and will provide insight into therapeutic strategies for low back injury prevention.

Interventions

Test group will receive one (1) topical application of capsaicin (Zostrix, 0.075%) to the L1-L5 dermatomes bilaterally. The capsaicin applied to each subject will not be standardized since we are not investigating dose responses; a thin layer of capsaicin will be applied to cover the dorsal skin areas bounded anatomically by the 12 rib line (superiorly), the lateral border of the trunk (laterally) and a transverse line through the posterior superior iliac spine (inferiorly).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 24 Years

Healthy volunteers

Yes

Inclusion criteria

young healthy subjects

Exclusion criteria

The Exclusion Criteria Include neurologic disorders (neuropathy, neurodegenerative conditions), previous history of low back pain (discogenic, mechanical, myofascial), current use of medication (anti-inflammatories, analgesics, anticonvulsants, antidepressants). History of low back injury (discogenic, mechanical) use of anticoagulant therapy, stroke or TIA, spine trauma, recent (<6 months) motor vehicle accident, lumbar spine surgery, hypertension, focal neurological symptoms (sensory/motor)

Outcome results