The effects of yoghurt and its probiotics on features of the metabolic syndrome, intestinal function, bone metabolism and quality of life; a randomised controlled trial.

In elderly persons at risk of metabolic syndrome, is yoghurt and/or its probiotics efficacious at improving features of metabolic syndrome?

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000033842

Enrollment

152

Registered

2012-01-09

Start date

2012-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a 6 week randomised controlled factorial study to evaluate the effects of yoghurt and its probiotics on risk of metabolic syndrome, quality of life, gastrointestinal health and bone metabolism.

Interventions

Arm 1: 200g/d Probiotic yoghurt consumed over a total of 6 weeks Arm 2: 3 x probiotic capsules/d consumed over a total of 6 weeks. Each capsule contains > 10 billion CFU probiotic bacteria

Study design

Allocation

Randomised controlled trial

Intervention model

Factorial

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

55 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Minimal usual probiotic intake (consuming less than 400 g yoghurt per week, and not taking probiotic supplements); AND 2. BMI greater than 25 kg/m2; AND 3. Waist circumference greater than 94 cm in men and 80cm in women OR blood pressure >120/80 mmHg

Exclusion criteria

1. Unlikely to complete the 6 week study 2. Intolerance to dairy foods 3. Unable to attend the study centre on 4 occasions over 9 weeks 4. Current antibiotic use 5. Patients on immunosuppressive 6. Type two diabetes requiring pharmaceutical treatment.

Outcome results