None listed
Conditions
Brief summary
This will be a retrospective study using existing demographic, clinical and MRI image data to develop HepaFatTM Scan, a non-invasive tool to quantify liver fat.
Interventions
HepaFat Scan is a magnetic resonance (MR) image analysis product to facilitate the non invasive quantification of fat within the liver. The technology is based on gradient recalled echo imaging using the technique of Dixon et al. However, several novel changes have been made to this established method to enable HepaFat Scan to provide greater degrees of sensitivity and specificity in measuring liver fat than other available methods. This will be a retrospective study using existing demographic, clinical and MRI image data (obtained between March 2009 and December 2011 and available in institutional databases) from 10 subjects without liver disease (healthy controls) and up to eighty (80) patients with liver disease. Neither patients nor healthy control subjects are required to undergo any additional procedures or MRI scans.
Sponsors
Eligibility
Inclusion criteria
Age 18-65 years Confirmed diagnosis of liver disease Liver biopsy within 12 months prior to entry into the study Alcohol consumption <20 grams/day for men and <10 grams/day for women.
Exclusion criteria
Inability to provide informed consent Contraindications for MRI Ischemic heart disease as determined by history or abnormal ECG. Pregnancy or lactation. Malignancy (excluding basal cell or squamous cell skin cancers)