Intraoperative magnesium infusion as an adjuvant to bilateral single-injection thoracic paravertebral block for laparoscopic cholecystectomy

the use of magnesium sulfate infusion as an adjuvant to thoracic paravertebral block for laparoscopic cholecystectomy decreases postoperative fentanyl consumption. a randomized, double blind,controlled trial.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12612000001897

Enrollment

Registered

2012-01-03

Start date

2010-04-03

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Background: Magnesium has antinociceptive effects. This study was designed to examine whether intraoperative administration of i.v magnesium with bilateral thoracic paravertebral block (PVB) enhances postoperative analgesia while reducing opioid consumption and opioid-related side effects. Methods: In this prospective randomized, double-blinded, controlled study, 59 patients undergoing laparoscopic cholecystectomy were given bilateral single injection PVB at the level of T5. Before induction of general anaesthesia, patients were assigned to two groups. Group M (magnesium group) received a loading dose of magnesium sulphate 30 mg per kg in 100 ml of normal saline over 10 min followed by an infusion of 10 mg per kgper h till the end of surgery. Control group (group C) received the same volume of normal saline as a loading dose followed by a continuous infusion. In both groups, postoperative pain was initially controlled by i.v. fentanyl titration and then fentanyl PCA. Cumulative PCA fentanyl consumption, pain intensities, sedation scores, cardiovascular and respiratory variables and opioid-related adverse effects were recorded for 36 h after operation.

Interventions

patients undergoing laparoscopic cholecystectomy were given bilateral single injection thoracic paravertebral block at the level of T5 with 25ml of 0.25% bupivacaine. Before induction of general anaesthesia, Group M (magnesium group) received a loading dose of magnesium sulphate 30 mg per kg in 100 ml of normal saline over 10 min followed by an infusion of 10 mg per kg per h till the end of surgery. Control group (group C) received the same volume of normal saline as a loading dose followed by

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

ASA I-II patients scheduled for laparoscopic cholecystectomy.

Exclusion criteria

history of cardiovascular disease or conduction disturbance, if they had impaired renal, hepatic or pulmonary functions, neuromuscular disease, coagulation disorder, obesity (body mass index >35kg.m2), a known allergy to magnesium sulphate, opioids or any other drug used in the study, or inability to use the patient-controlled analgesia (PCA) system).

Outcome results