Use of serial 18F-fluorodeoxyglucose (FDG) and 18F-fluorothymidine (FLT) positron emission tomography (PET) & computed tomography (CT) for candidates with non-small cell lung cancer (NSCLC)receiving radical chemo-radiation therapy

A prospective study to investigate the impact of serial FDG and FLT PET scans on the radiation therapy treatment of patients with NSCLC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12611001283965

Enrollment

Registered

2011-12-15

Start date

2008-10-23

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to prospectively explore the anatomical and biological characteristics of non-small cell lung cancers (NSCLC) in patients receiving combined radiation therapy (RT)-chemotherapy treatment with a curative intent. Patients will undergo PET/CT scans during the course of their treatment using two different PET tracers. The first tracer, 18F-FDG, is a proven tracer in current clinical use used to detect glucose metabolism. The second, 18F-FLT, is a novel tracer that can visualize cellular division rates in tumour compared to normal tissue.

Interventions

FDG and FLT PET/CT scans at baseline, during week two and week four of therapy. Each scan involves the injection of a radiotracer (FDG or FLT). Each scan is approximately 30 minutes in duration. Patients will be recruited over a five year period.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Written informed consent provided. Histologically or cytologically confirmed NSCLC. Candidate for radical RT (60Gy) & concomitant chemotherapy (standard regimen determined by medical oncologist). Stage I - III disease (TNM 7th edition). ECOG performance status 0-1.

Exclusion criteria

Received previous thoracic RT or a complete macroscopic excision of tumour. Pregnancy (Women of child-bearing age to ensure adequate contraceptive measures).

Outcome results