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Assessment of auto-titrating positive airways pressure in the management of treatment-related aerophagia.

Assessment of auto-titrating positive airways pressure in the management of treatment-related aerophagia and its impact on usage and quality of life measures.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12611001250921
Enrollment
56
Registered
2011-12-06
Start date
2009-06-22
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Patients who suffer from Obstructive Sleep Apnoea, a disorder where the airway closes during sleep, are often prescribed treatment with CPAP (Continuous Positive Airways Pressure). This is a device that blows air down the airway via a face mask. Some patients experience stomach bloating as a result of this therapy. This research aims to try an alternative treatment, APAP (Automatic Positive Airways Pressure), to assess if this is better tolerated in these patients. APAP delivers the pressure by sensing when the airway closes and only increasing if necessary. Patients will use CPAP for two weeks and APAP for two weeks (in random order) to see which treatment is best tolerated. We propose that treatment with APAP will result in more effective and comfortable therapy. Patients who currently discontinue or struggle with CPAP due to these side-effects will have a reasonable alternative.

Interventions

Patients will be assigned to using an auto-titrating positive airways pressure device overnight for 2 weeks. Auto-titrating positive airways pressure devices treat obstructive sleep apnea by delivering pressurised air via a hose to a mask interface. It delivers the pressure by sensing when the airway closes and only increasing the pressure if necessary. This is a crossover study and there is no washout period between treatments.

Sponsors

The Princess Alexandra Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients who have reported symptoms of aerophagia whilst on continuous positive airways pressure therapy for obstructive sleep apnea.

Exclusion criteria

Pregnant women and patients with intellectual or mental impairment.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 9, 2026