None listed
Conditions
Brief summary
The purpose of this study is to determine if nutrients that have been shown to improve blood flow and increase circulating insulin-like growth factor 1 concentrations in the blood can improve both blood flow in the ovary and elevate the concentration of insulin-like growth factor 1 in the follicular fluid surrounding the eggs. The ability to increase the concentration of IGF-1 in follicular fluid surrounding the eggs in the ovary in this way may provide an inexpensive and simple alternative to growth hormone treatment for improving egg quality in patients undergoing IVF treatment.
Interventions
Participants will undergo their usual IVF treatment, but from the 3rd day of the IVF cycle they will be asked to consume 250ml of a milk-based drink in the morning and evening that will contain active components that might increase ovarian blood flow and follicular fluid insulin-like growth factor 1 concentrations, or a placebo. They will continue to consume the 250ml drink daily until the end of their IVF stimulation cycle. At the start and end of their cycle a blood sample will be collected to
Participants will undergo their usual IVF treatment, but from the 3rd day of the IVF cycle they will be asked to consume 250ml of a milk-based drink in the morning and evening that will contain active components that might increase ovarian blood flow and follicular fluid insulin-like growth factor 1 concentrations, or a placebo. They will continue to consume the 250ml drink daily until the end of their IVF stimulation cycle. At the start and end of their cycle a blood sample will be collected to measure circulating IGF-1 concentrations and the concentrations of reproductive hormones. During their routine day 9/10 follicle tracking scan, blood flow to the ovaries will also be measured using ultrasound. When their eggs are retrieved at the end of their IVF cycle the follicular fluid surrounding the eggs will be collected and analysed for IGF-1 and reproductive hormone concentrations.
Sponsors
University of South Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
Undergoing a gonadotrophin-releasing hormone antagonist cycle of IVF treatment and a poor responder to ovarian hyperstimulation. This includes meeting two of the following three criteria: 1. 40 years or older 2. previously only produced 3 or less mature eggs in response to maximal dose ovarian stimulation during IVF treatment 3. serum anti-mullerian hormone concentration < 7.8 pmol/l or a total antral follicle count <7 (both being accurate markers suggesting a reduced number of eggs left within your ovaries relative to your age).
Exclusion criteria
intolerant/allergic to cow's milk protein, lactose, soy, wheat, egg, gluten, nuts or seeds, concurrent use of human growth hormone, Elonva, long down regulation IVF cycle, oral corticosteroids (Prednisolone) therapy have used dehydroepiandrosterone therapy in last month
Outcome results
None listed