None listed
Conditions
Brief summary
Exercise therapy, in particular aerobic exercise, in the CKD population has been shown to decrease cardiovascular risk factors and subsequent CVD, however there has been little work comparing the effectiveness of different exercise prescriptions. Furthermore, patients with CKD endure significant muscle wasting which greatly impacts on their ability to complete day to day activities and their quality of life. The primary measure will be cardiorespiratory fitness, measured as maximal oxygen uptake using expired air gas analysis during an exercise stress test. Additionally, although previous studies in chronic disease populations have demonstrated exercise therapy to be effective in reducing muscle wastage, the intensity of the training required for maximum benefits is still equivocal. The effects of training intensity on muscle wasting will be assessed through whole body composition dual x-ray absorptiometry. As the mechanisms of the persistent loss of muscle mass observed in patients with CKD is poorly understood, this study also aims to investigate the effects of exercise training on pathways of muscle breakdown. To investigate the mechanisms, plasma samples will be collected and muscle biopsies will be performed before and after the training.
Interventions
Arm 1- high intensity interval training
Arm 2- moderate intensity continuous training
Arm 3- control group
Intervention: The study will consist of 3 groups- 2 exercise interventions and a control group. Supervised by an accredited Exercise Physiologist, the 2 exercise interventions of high intensity interval training (HIIT) and moderate continuous training (MCT) will be completed over 12 weeks. The control group will undergo usual medical practitioner care. The exercise intervention groups will
Arm 1- high intensity interval training Arm 2- moderate intensity continuous training Arm 3- control group Intervention: The study will consist of 3 groups- 2 exercise interventions and a control group. Supervised by an accredited Exercise Physiologist, the 2 exercise interventions of high intensity interval training (HIIT) and moderate continuous training (MCT) will be completed over 12 weeks. The control group will undergo usual medical practitioner care. The exercise intervention groups will complete 3 supervised training sessions per week. The two exercise interventions will be iso-caloric meaning that the MCT group will train for longer during each session. Exercise intensities will be monitored using heart rate monitors and the peak heart rate (PHR) that will be obtained during the exercise stress test. Exercise Intensities: HIIT: 1:00 minute intervals (90-95%), 1:00 minute active recovery (60-70% PHR) MCT: ~40 minutes continuous exercise (60-70% PHR) Exercise Modalities: The modality of the equipment utilized in the exercise intervention will differ each session between 3 pieces of equipment. These will include treadmill walking/running, rowing and cycle ergometer. The high intensity interval will involve walking up a hill or running on the treadmill (depending on the persons capabilities), or changing the resistance or speed on the rower and bike.
Sponsors
School of Human Movement Studies, University of Queensland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria: Completion of Landmark 3 study Aged 18-75 Stage 3 or 4 chronic kidney disease (eGFR >25ml/min or <60ml/min)
Exclusion criteria
Exclusion criteria: Unable or unwilling to give informed consent Pregnant Life expectancy less than 6 months Current involvement in other research studies Organ transplant History of significant coronary artery disease
Outcome results
None listed