None listed
Conditions
Brief summary
The primary purpose of this study is to investigate and trial a combined therapy of novel medication and speech pathology for a persistent cough that hasn't previously responded to typical medical treatment. We will compare this program to individual component treatments of medication or speech pathology with the aim of significantly reducing cough symptoms and cough severity. Our ultimate goal is to resolve the cough resulting in a significant improvement in patient quality of life.
Interventions
Arm 1: Pregabalin, Up to 3x75 mg per day for 12 weeks, maximum dose 300 mg/day, oral route
Arm 2: Speech pathology 4 step intervention for chronic cough, administered one on one with speech pathologist. Four steps include cough education, cough counselling, behavioural therapy such as swallowing technique, lifestyle intervention such as vocal hydration and at least one of these components will addressed at each visit depending on individual needs and understanding of the techniques by the partic
Arm 1: Pregabalin, Up to 3x75 mg per day for 12 weeks, maximum dose 300 mg/day, oral route Arm 2: Speech pathology 4 step intervention for chronic cough, administered one on one with speech pathologist. Four steps include cough education, cough counselling, behavioural therapy such as swallowing technique, lifestyle intervention such as vocal hydration and at least one of these components will addressed at each visit depending on individual needs and understanding of the techniques by the participant. Each session will last for approximately 1 hour every 3 weeks for 12 weeks duration.
Sponsors
John Hunter Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Persistent cough lasting for 8 or more weeks that has not responded to medical treatment or persistent cough 8 or more weeks duration with no diagnosis. Non-smoker or ex-smoker.
Exclusion criteria
Productive cough with purulent sputum Current smoker Smoking related respiratory disease Pregnant/Breast Feeding Other active respiratory disease such as COPD RTI during month prior to randomisation Impaired liver function Untreated asthma, reflux, rhinosinusitis Psychiatric disorder or currently receiving medical treatment for psychiatric disorder.
Outcome results
None listed