None listed
Conditions
Brief summary
We will recruit 200 patients with T2DM between the ages of 25 and 65 with no history of coronary artery disease (CAD) or cardiovascular complications. We anticipate numbers of men and women to be roughly equal. All testing will take place at Princess Alexandra Hospital in the cardiovascular clinical measurements department and intensive exercise sessions will also be held at the Princess Alexandra hospital in the cardiovascular imaging research centre gym. The primary outcome variable of this study will be: 1. Increased capillary recruitment and glycaemic control Secondary outcomes measures will be: 1. Improvement in left ventricular systolic and diastolic function 2. Improvement in functional capacity.
Interventions
Exercise intervention to improve blood flow to skeletal muscle thereby decreasing insulin resistance and improving gycaemic control. Those randomised to the intervention will participate in a 12 week intensive exercise program 3 times per week (1 hour) consisting of a combination of aerobic and resistance exercises tailored to the patient. They will then be given a home exercise program tailored to them by an accredited exercise physiologist. The intensive exercise program will be repeated a
Exercise intervention to improve blood flow to skeletal muscle thereby decreasing insulin resistance and improving gycaemic control. Those randomised to the intervention will participate in a 12 week intensive exercise program 3 times per week (1 hour) consisting of a combination of aerobic and resistance exercises tailored to the patient. They will then be given a home exercise program tailored to them by an accredited exercise physiologist. The intensive exercise program will be repeated at the end of one year. Exercise sessions will be in small groups approximately 6-8 participants.
Sponsors
University of Queensland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
25 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Type 2 diabetes able to exercise
Exclusion criteria
history of any cardiovascular disease history of stroke end stage renal disease pregnancy terminal disease
Outcome results
None listed