High vs low urine output targets in surgical patients.

High vs. Low Urine Output Targets in Surgical Patients: a randomised assessor-blinded safety study.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611001157965

Acronym

TRENAL

Enrollment

Registered

2011-11-04

Start date

2011-11-28

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a randomised controlled trial comparing a low urine output target to a high urine output target in the context of bowel resection.

Interventions

For the first 48 hours from the start of surgery, participants undergoing elective bowel resection will have their perioperative fluid management guided by a urine output target of 0.2 ml/kg/h. If a particpant's urine output falls below this limit, they will bolused with 500mls of intravenous fluid over 15 minutes to raise their urine output above the required target. Their urine output will be checked hourly and the processed repeated should it fall below the required target.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

Patients undergoing elective bowel resection

Exclusion criteria

Preexisting kidney disease or damage, perioperative nephrotoxic substance administration, pre-existing hepatic failure, ASA class IV, morbid obesity, pregnant or lactating females.

Outcome results