None listed
Conditions
Brief summary
IL6,CRP,SSA and MPO have a important role in a diagnosis and prediction of mortality in myocardial infarction(MI).some studies have mentioned the anti-inflammatory effect of heparin and enoxaparin.There is no study that is shown which drug has a better effect in decreasing inflammatory bio markers. The primary purpose of this study is to find that if enoxaparin and heparin can reduce inflammatory factors and which drug has a better effect in decreasing that bio markers?
Interventions
Arm1: STEMI patients ,Intravenous bolus Heparin(60 IU/kg followed by 1000 IU per hour continuous infusion to achieve an aPTT of 50-75 seconds,48 hours)The minimum duration of heparin therapy after MI is generally 48 hours, but it may be longer, depending on the individual clinical scenario.
Arm 2: STEMI patients ,enoxaparin (1mg/kg sub cutaneous every 12 hr ,48 hours)The minimum duration of enoxaparintherapy after MI is generally 48 hours, but it may be longer, depending on the individual clinic
Arm1: STEMI patients ,Intravenous bolus Heparin(60 IU/kg followed by 1000 IU per hour continuous infusion to achieve an aPTT of 50-75 seconds,48 hours)The minimum duration of heparin therapy after MI is generally 48 hours, but it may be longer, depending on the individual clinical scenario. Arm 2: STEMI patients ,enoxaparin (1mg/kg sub cutaneous every 12 hr ,48 hours)The minimum duration of enoxaparintherapy after MI is generally 48 hours, but it may be longer, depending on the individual clinical scenario.
Sponsors
Tehran university of medical science
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
age >18 patients with definite STEMI diagnosis
Exclusion criteria
1-history of AMI or CHF or AF 2-history of liver( LFT> 3ULN), kidney(Cr>2 or Cr > 25% increase in baseline),thyroid disease or malignancy 3-acute or chronic infection or autoimmune disease 4- treatment with heparin or enoxaparin before study 5-pregnancy or breastfeeding 6-treatment with anti-inflammatory drug during 3 mounths ago
Outcome results
None listed