Follow-up of children whose mothers participated in the DOMINO trial: does fish oil supplementation in pregnancy influence child development at 4 years?

Does maternal supplementation with n-3 long-chain PUFA in pregnancy influence cognitive development in childhood?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611001125910

Acronym

The DOMInO 4 Study

Enrollment

709

Registered

2011-10-27

Start date

2010-06-18

Completion date

2010-09-25

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aim is to determine whether supplementing pregnant women with DHA-rich capsules from 18-21 weeks of prengnacy until delivery will enhance the general cognitive ability of children at 4 years of age. Hypothesis: Children whose mothers took DHA-rich fish oil capsules during the second half of pregnancy will have enhanced cognitive development at 4 years of age compared with children whose mothers consumed a placebo. This will be investigated using psychometric assessments.

Interventions

3 x 0.5 DHA rich Tuna Oil Capsules taken daily from 18-21 weeks until birth of child in The DOMInO Study.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

4 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Children who were included in the secondary outcome (neurodevelopment at 18months as assessed by the BSIDIII) of the original DOMInO Trial .

Exclusion criteria

nil

Outcome results