None listed
Conditions
Brief summary
Samll pilot cross over study comparing two differen tmean arterial pressures in patient having cardiac surgery
Interventions
Increase in mean arterial pressure with intravenous noradrenaline infusion.
Noradrenaline will be infused through a central venous catheter at th enecessary dose to achieve and maintain a MAP 20 mmHg grater than baseline for 30 minutes while the patient is on cardiopulmonary bypass and for 2 hours after the patient is returned to ICU.
The noradrenaline infusion will then be decreased after such period and the patient returned to baseline levels.
This cross over will have no washout period.
Aft
Increase in mean arterial pressure with intravenous noradrenaline infusion. Noradrenaline will be infused through a central venous catheter at th enecessary dose to achieve and maintain a MAP 20 mmHg grater than baseline for 30 minutes while the patient is on cardiopulmonary bypass and for 2 hours after the patient is returned to ICU. The noradrenaline infusion will then be decreased after such period and the patient returned to baseline levels. This cross over will have no washout period. After the noradrenaline infusion, patients will then be immediately crossed over to the standard care arm,
Sponsors
Austin Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
Open heart cardiac surgery Ability to insert a hepatic venin cannula Informed consent
Exclusion criteria
Inability to insert hepatic vein catheter Emergency surgery Severe disorder of coagulation Lack of informed consent Jeovah's witness Pregnancy
Outcome results
None listed