None listed
Conditions
Brief summary
This study will assess whether cereals can improve mineral bioavailability in postmenopausal women.
Interventions
We will be testing 4 cereals that differ in their nutrient composition. The 4 cereal types will deliver 1. high, 2. moderate-high, 3. moderate or 4. low (negative control) levels of dietary fibre. For the study duration participants will follow their habitual dietary pattern with some restrictions to ensure it is low in fibre. This is a parallel study design, with participants randomised to one of four groups. Participants will be asked to consume 100g of the test food daily for an 8 week testin
We will be testing 4 cereals that differ in their nutrient composition. The 4 cereal types will deliver 1. high, 2. moderate-high, 3. moderate or 4. low (negative control) levels of dietary fibre. For the study duration participants will follow their habitual dietary pattern with some restrictions to ensure it is low in fibre. This is a parallel study design, with participants randomised to one of four groups. Participants will be asked to consume 100g of the test food daily for an 8 week testing period. At baseline participants will undergo a DXA total body, forearm and lumbar spine scan. Each fortnight participants will attend the clinic for a fasted blood sample and to complete 2 short questionnaires (product consumption checklist and 3 day food diary) and prior to the visit collect a 48 hour urine. At week 8 participants will undergo a dual stable isotope test.
Sponsors
CSIRO Food Futures National Research Flagship
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
0 to 75 Years
Healthy volunteers
Yes
Inclusion criteria
female, aged <75 years, postmenopausal >6years and not undergoing hormone replacement therapy. Not on vitamin or mineral supplements or unwilling to abstain for the duration of the study. Not received any medication that in the opinion of the investigator could interfere with the study and no medications likely to modulate gut and/or metabolic function.
Exclusion criteria
Bone mineral density in the osteoporotic density range. Intolerance to lactose. Use of any form of drug therapy or medication or supplements that may interfere with bowel or bone function (such as antibiotics, laxatives, osteoporotic treatments etc). Known or suspected personal history or family history of adverse events, hypersensitivity or intolerance to consumption plant-based foods which will be tested in this study.
Outcome results
None listed