A 2hr Accelerated Diagnostic Protocol to Assess patients with chest Pain symptoms using contemporary Troponins as the only biomarker (ADAPT): a prospective observational validation study

Conditions

None listed

Brief summary

This is a prospective observational study of the diagnostic utility of an accelerated diagnostic protocol using a central laboratory Troponin I in people presenting to the Emergency Deprtment with chest pain of probable caridac origin. A blood sample will be taken and tested on arrival and again at 2 hours. Participants will undergo risk evaluation by a means of a set series of questions. Patients will be followed-up to determine outcomes at 30 days and 1 year after presentation

Neumann JT, Twerenbold R, Ojeda F, Aldous SJ, Allen BR, Apple FS, Babel H, Christenson RH, Cullen L, Di Carluccio E, Doudesis D, Ekelund U, Giannitsis E, Greenslade J, Inoue K, Jernberg T, Kavsak P, Keller T, Lee KK, Lindahl B, Lorenz T, Mahler SA, Mills NL, Mokhtari A, Parsonage W, Pickering JW, Pemberton CJ, Reich C, Richards AM, Sandoval Y, Than MP, Toprak B, Troughton RW, Worster A, Zeller T, Ziegler A, Blankenberg S, ARTEMIS study group.

2023-05-0220 citations

10.1007/s00392-023-02206-3

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

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Diagnosis of acute myocardial infarction in the presence of left bundle branch block

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Heart2019-05-2940 citations

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Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction

Noreen van der Linden, Karin Wildi, Raphael Twerenbold, John W. Pickering, Martin Than et al. (42 authors)

Circulation2018-04-2486 citations

10.1161/circulationaha.117.032003

Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy

Edward Carlton, John W. Pickering, Jaimi Greenslade, Louise Cullen, Martin Than et al. (10 authors)

Heart2017-09-0119 citations

10.1136/heartjnl-2017-311983

The organisational value of diagnostic strategies using high-sensitivity troponin for patients with possible acute coronary syndromes: a trial-based cost-effectiveness analysis

Paul Jülicher, Jaimi Greenslade, William Parsonage, Louise Cullen

BMJ Open2017-06-0136 citations

10.1136/bmjopen-2016-013653

Direct Comparison of 2 Rule-Out Strategies for Acute Myocardial Infarction: 2-h Accelerated Diagnostic Protocol vs 2-h Algorithm

Karin Wildi, Louise Cullen, Raphael Twerenbold, Jaimi Greenslade, William Parsonage et al. (25 authors)

Clinical Chemistry2017-05-1737 citations

10.1373/clinchem.2016.268359

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Heart2016-06-1029 citations

10.1136/heartjnl-2016-309270

Time to presentation and 12-month health outcomes in patients presenting to the emergency department with symptoms of possible acute coronary syndrome

Louise Cullen, Jaimi Greenslade, Louven Menzies, Ashley Leong, Martin Than et al. (12 authors)

Emergency Medicine Journal2016-01-1818 citations

10.1136/emermed-2015-204978

The incremental value of stress testing in patients with acute chest pain beyond serial cardiac troponin testing

Sally Aldous, Mark Richards, Louise Cullen, John W. Pickering, Martin Than

Emergency Medicine Journal2015-10-2819 citations

10.1136/emermed-2015-204823

Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome.

Cullen L, Mueller C, Parsonage WA, Wildi K, Greenslade JH, Twerenbold R, Aldous S, Meller B, Tate JR, Reichlin T, Hammett CJ, Zellweger C, Ungerer JPJ, Rubini Gimenez M, Troughton R, Murray K, Brown AFT, Mueller M, George P, Mosimann T, Flaws DF, Reiter M, Lamanna A, Haaf P, Pemberton CJ, Richards AM, Chu K, Reid CM, Peacock WF, Jaffe AS, Florkowski C, Deely JM, Than M.

2013-04-10218 citations

10.1016/j.jacc.2013.02.078

2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial.

Than M, Cullen L, Aldous S, Parsonage WA, Reid CM, Greenslade J, Flaws D, Hammett CJ, Beam DM, Ardagh MW, Troughton R, Brown AF, George P, Florkowski CM, Kline JA, Peacock WF, Maisel AS, Lim SH, Lamanna A, Richards AM.

2012-05-09275 citations

10.1016/j.jacc.2012.02.035

Interventions

A risk assessment will be made using the TIMI score , ECG and measurements of central lab Troponin I taken from people who present with probable ischaemic chest pain to the Emergency Department. A sample is tested on arrival and again 2 hours later. ADAPT and ASPECT both started in Christchurch in November 2007 final recruitment for ASPECT occured in Singapore in July 2010; recruitment for ADAPT finished in Brisbane February 2011

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

Adults presenting to the trial hospital Emergency Department with chest pain of possible cardiac origin

Exclusion criteria

Age < 18 years. Non-resident in country of recruitment. Patients for whom follow-up will not be possible either due to lack of onward contact address or because they will be overseas. Unable or unwilling to consent

Outcome results