Granisetron and incidence of shivering in children after spinal anesthesia

Premedication with Granisetron prevents shivering during spinal anaesthesia in children

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611001059954

Enrollment

Registered

2011-10-11

Start date

2011-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

80 children aged from 2-5 years scheduled for surgery in lower limb were prepared for spinal anesthesia. Children were classified into two groups, Group 1 (40 children) received intravenous 10 mcg/Kg granisetron diluted in 10 ml saline 0.9% and Group 2 (40 children) received intravenous 10 ml 0.9% saline to be given over 5 minutes just before spinal puncture. Shivering, core temperature levels of motor and sensory block were assessed.

Interventions

Effect of Premedication with Granisetron on incidence of shivering during spinal anesthesia in children intravenous 10 mcg/Kg granisetron diluted in 10 ml saline 0.9% to be given over 5 minutes just before spinal puncture. Spinal block was done by intrathecal hyperbaric bupivacine 0.5% (0.5 mg/Kg).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

2 Years to 5 Years

Healthy volunteers

Inclusion criteria

80 children ASA 1 and 2 scheduled for lower limb surgery under spinal anaesthesia were entered into study

Exclusion criteria

Exclusion criteria included: refusal of parents, coagulopathy, spinal congenital anomalies, neurological abnormality, allergy to local anesthetics and surgery scheduled to last for more than 90 minutes, children with hypo or hyperthyroidism, children with hypothermia or hyperthermia and those who needed intraoperative blood transfusion.

Outcome results