None listed
Conditions
Brief summary
The primary purpose of the study is to conduct a clinical trial on the use of HFNP therapy on infants with viral bronchiolitis requiring ventilator support and compare it with the standard care at the Campbelltown and Mt Druitt Hospitals to see effect of HFNP therapy in reducing the need for intubation and cost of transferring children to specialized children hospitals.
Interventions
High flow nasal prong therapy
Children with viral bronchiolitis requiring more than 2L/min oxygen will receive treatment as per protocol A (Control) or B (Treatment)
Protocol B:
-Patient given HFNP providing humidified and warmed to 37 degrees.
-The flow rate, set to optimise oxygen saturation, will be up to 8 L/min depending on patient comfort
-Duration of HFNP will vary depending on severity of the bronchiolitis. Breaks for nasal care or mobilization will be permitted.
-Other treatments such
High flow nasal prong therapy Children with viral bronchiolitis requiring more than 2L/min oxygen will receive treatment as per protocol A (Control) or B (Treatment) Protocol B: -Patient given HFNP providing humidified and warmed to 37 degrees. -The flow rate, set to optimise oxygen saturation, will be up to 8 L/min depending on patient comfort -Duration of HFNP will vary depending on severity of the bronchiolitis. Breaks for nasal care or mobilization will be permitted. -Other treatments such as drug therapy will be given according to standard protocols
Sponsors
Prof John Whitehall
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to 24 Months
Healthy volunteers
No
Inclusion criteria
*Male or female *Clinical features typical of viral bronchiolitis *Clinical features and SpO2 compatible with moderate to severe bronchiolitis
Exclusion criteria
*Complications of bronchiolitis discovered before enrolment, including pneumothorax *Pneumonia plus or minus bronchiolitis *Rapid progression of illness preventing opportunity for informed consent of parents or guardians.
Outcome results
None listed