Can certain anaesthesia medications & techniques provide additional benefits after cancer surgery apart from pain relief and speed of recovery from that surgery (LIPO trial - Lignocaine infusion given peri-operatively)

Can anaesthetic technique in the form of peri-operative lignocaine infusion to blunt surgical stress response have additional benefits in long term outcome following primary cancer surgery

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611001005943

Acronym

LIPO (Lignocaine Infusion Peri-operatively)

Enrollment

600

Registered

2011-09-20

Start date

2011-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intra-operative lignocaine infusion. Replica of methodology from existing study, specifically Kuo et al, British Journal of Anaesthesia, 97 (5): 640–6 (2006): 2mg/kg over 15 mins, followed by 3mg/kg/hr IV. Continued intra-op and 30 mins post op. Intraoperative top-up fentanyl and post operative morphine patient controlled analgesia (PCA) if required. Additional resource [ANZCTR no: 12609001073291] & Annals of Surgery - Volume 246, Number 2, August 2007 page 192 - slight modification in met

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

Non metastatic cancer requiring primary surgery: Colectomy, nephrectomy, prostatectomy, hysterectomy, melanoma excision, mastectomy, cystectomy

Exclusion criteria

Metastases ASA 4 and above Diabetes Concurrent pre-operative opioid analgesic use Anti arrythmic drugs, arrythmogenic conditions Hepatic or renal impairment Pregnancy

Outcome results