Whether the antioxidants can prevent patients with obstructive jaundice from the hypotension in operation.

Compared with controls ,whether the treatment of antioxidants can alleviate vascular hyporesponsiveness in patients with obstructive jaundice

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000980932

Enrollment

Registered

2011-09-14

Start date

2011-10-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

1.Vascular hyporesponsiveness in patients with obstructive jaundice is a common problem during operation. It causes high complication and high mortality during preoperative period. But the mechanism is still unknown. There is still no effective method to prevent and treat vascular hyporesponsiveness. 2.Patients with obstructive jaundice produce great amount of Recative Oxygen Species(ROS). The excessive ROS seem to have two effects on blood vessel by the a-advenergic receptors(a-AR). The acute and short-term effect changes the expression, affinity, phosphorylation level of a-AR and cause the decreased contractility of blood vessel. The chronic and long-term effect causes the remodeling of blood vessel by a-AR signal pathway through cell hypertrophy, hyperplasia and apoptosis. These two effects may result in vascular hyporesponsiveness. 3.Therefore, the present research focuses on the vascular hyporesponsiveness in patients with obstructive jaundice caused by ROS through a-AR. The research may put forward feasible explanations of unstable haemodynamics in obstructive jaundice patients. It may also offer a new target to prevent and treat the unstable haemodynamics to increase the preoperative safety in obstructive jaundice patients.

Interventions

Glutathione reduced by Intravenous injection,240mg,every day,7 days before abdominal operation

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

Male

Age

50 Years to 70 Years

Healthy volunteers

Inclusion criteria

participants with obstructive jaundice(serum total bilirubin>100umol/L)caused by neoplasm of the bile duct or the head of the pancreas who will undergo abdominal operation

Exclusion criteria

females,<50 years >70 years,BMI>30kg/m2 <18kg/m2,diabetes,cardiovascular diseases

Outcome results