Intra-articular injections of hyaluronic acid in osteoarthritis of the sub-talar joint: A prospective study

In patients with subtalar osteoarthritis, does hyaluronic acid improve pain and daily function?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000977976

Enrollment

Registered

2011-09-13

Start date

2008-09-04

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The management for osteoarthritis (OA) of the sub-talar joint is primarily conservative. We evaluated the efficacy of intra-articular viscosupplementation with sodium hyaluronate (HA) in the management of OA of the sub-talar joint.

Interventions

Intra-articular injections of 10 mg HA were administered weekly to the sub-talar joint for 3 weeks

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Healthy volunteers

Inclusion criteria

We included patients suffering from OA of the sub-talar joint grades II-III according to Paley Hall sub-talar joint grading system and grades II-IV according to the Kellgren & Lawrence. All patients complained of pain on motion or rest for at least 6 months and had swelling and tenderness of the sub-talar joint.

Exclusion criteria

Exclusion criteria included non-walking patients, those with an ankylosed subtalar joint, suspected or proven previous sub-talar joint infection, and those with known hypersensitivity to hyaluronic acid, pregnant or lactating women, patients with concomitant disease that may affect joints, those with open wounds or skin ulcers, and those taking anticoagulants or having a prolonged bleeding time. Patients who had undergone lower limb intra-articular injection or surgery, including arthroscopy, within the previous 6 months were also excluded.

Outcome results