Efficacy of Triple Antibiotic Therapy in Symptomatic Blastocystis patients

In patients with symptomatic Blastocystis, is triple antibiotic therapy effective in clearing Blastocystis from the stool and improving clinical well-being?

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000918921

Acronym

Nil

Enrollment

Registered

2011-08-29

Start date

2011-08-09

Completion date

2014-02-20

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We intend to evaluate the efficacy of 14 days of the triple antibiotics listed above in eradicating Blastocystis infection in symptomatic patients.

Interventions

Administration of 14 days of oral capsule antibiotics: specifically trimethoprim/sulfamethoxazole 160/800mg twice daily, diloxanide furoate 500 mg three times daily and secnidazole 400mg three times daily

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

Gastrointestinal symptoms No other cause except Blastocystis found on investigation Good general health

Exclusion criteria

Allergy to Sulphurs Pregnancy or risk of pregnancy

Outcome results