The effect of routine reversal of neuromuscular blockade on surgical conditions for thyroid surgery

The effect of routine reversal using neostigmine, of neuromuscular blockade, on neuromuscular monitoring of the laryngeal nerve during thyroid surgery- a double blinded randomised control trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000914965

Enrollment

Registered

2011-08-25

Start date

2011-08-30

Completion date

2012-07-12

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Participants will receive a standard anaesthetic with- propofol induction, remifentanil induction, 2x ED 95 (intubating conditions) atracurium 0.4mg/km, sevoflurane, dexamethasone and cefazolin. At 30 mins post induction patients will either get neostigmine/glycopyrrolate injection or saline injection prepared by an independent person, given by anaesthetist. Then the surgeon will determine, using the NIM stimulator whether the reversal of neuromuscular blockade is adequate.

Interventions

Atracurium 0.4mg/kg given as an intubating dose, given intravenously as a bolus, then reversal at 30 mins with neostigmine 2.5mg and glycopyrrolate 0.4mg, intravenously as a bolus, if in the study arm

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver)

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

Thyroid surgery at Peninsula Health

Exclusion criteria

Allergy to atracurium Musculoskeletal abnormality Surgeon not using NIM stimulation intraoperatively Recurrent laryngeal nerve injury/abnormality

Outcome results